Overview, Causes, & Risk Factors
Emphysema is a type of chronic obstructive airway disease, or COPD. People with COPD have limitations in the flow of air through their airways. Emphysema involves the gradual destruction of alveoli in the lungs. The alveoli are air spaces where oxygen is exchanged with carbon dioxide in the blood.
What is going on in the body?
The most common cause of emphysema is smoking. Long-term exposure to smoke causes destruction of the alveoli. The ability of the lungs to provide oxygen to the body decreases. As a result, the person finds it increasingly difficult to breathe and to exercise without discomfort.
The World Health Organization, or WHO, has recently developed a classification system for the severity of emphysema and other forms of COPD. There are four stages of severity, as outlined below:
What are the causes and risks of the disease?
Cigarette smoking is the most common cause of emphysema. The risk goes up with the amount of tobacco smoked and the number of years of smoking. Emphysema is most common in countries where smoking is prevalent. It is less common in countries where people smoke less. Passive smoking, or exposure to secondhand smoke, does increase a person’s risk for emphysema.
No one knows why only 10% to 15% of smokers get emphysema. Scientists think that certain people are predisposed because of their genes. Another theory is that infections or asthma in childhood makes airways more sensitive to damage. Some think that deeper inhalation of cigarette smoke may deposit more chemicals in the lungs.
Some people produce too little alpha-1-antitrypsin, a protective enzyme secreted in the lungs. These people are much more likely to develop emphysema at an early age, even without exposure to cigarette smoke.
Following are some of the other risk factors for emphysema:
Symptoms & Signs
What are the signs and symptoms of the disease?
Emphysema causes shortness of breath. People with emphysema are often unable to catch their breath with various levels of exercise. Unless the disease is halted, the breathing problems will get worse. In many cases, people will find themselves breathless even at rest.
People with severe emphysema cannot catch their breath when they lie down to sleep. This is called orthopnea. It forces them to get what little rest they can while sitting propped on a pillow or sleeping in a chair.
Other symptoms of emphysema include the following:
Diagnosis & Tests
How is the disease diagnosed?
Diagnosis of emphysema begins with a medical history and physical examination. Lung function tests can identify emphysema in Stage 0, even before the individual has symptoms. Lung function tests measure how much air a person can take in with a deep breath. They also measure how fast the person can push the air back out of the lungs. The healthcare provider may also order a chest X-ray and blood tests.
Prevention & Expectations
What can be done to prevent the disease?
Many risk factors for emphysema can be completely eliminated. Smoking cessation is vital for those who smoke. Sources of indoor air pollution can be identified and removed. It’s important to avoid secondhand smoke.
What are the long-term effects of the disease?
Chronic obstructive pulmonary diseases, including emphysema, are the fourth leading cause of death in the world. The long-term effects depend on how severe the disease is when diagnosed and if a reduced exposure to the lung irritant occurs. The most effective treatment is quitting smoking. This will typically result in a modest improvement or no further decline in function.
People with emphysema have a higher mortality than those with normal lung function. Causes of death include respiratory failure, lung infections such as pneumonia and influenza, and other diseases related to smoking. These include cancer, heart disease, and stroke.
Eventually, severe shortness of breath will limit the person’s normal daily activities. People who continue to smoke will have worsening shortness of breath. They may have panic attacks when they are unable to get enough air in and out. People with advanced emphysema are often incapacitated. They are short of breath even when confined to a chair or bed.
What are the risks to others?
Emphysema is not contagious and poses no risk to others.
Treatment & Monitoring
What are the treatments for the disease?
WHO has identified four components for management of emphysema. These include the following:
Assessment and monitoring
Assessment and monitoring of the disease incorporates the following steps:
Reducing risk factors
Reducing the person’s risk factors includes the following measures:
Managing stable emphysema
Management of stable emphysema includes the following:
WHO recommendations for management of emphysema are broken down by the severity of the disease. Following are the recommendations for Stage 0 emphysema:
Recommendations for Stage I emphysema are the same as those for Stage 0. In addition, people with Stage I emphysema should use short-acting bronchodilators as needed. Bronchodilators relieve cough and shortness of breath by opening the airways. In general, WHO recommends inhaled bronchodilators rather than oral medications.
Recommendations for Stage II emphysema include the recommendations from Stage I. The following additional measures are recommended for times when symptoms are present.
WHO recommendations for Stage III emphysema are as follows:
Managing worsening symptoms.
People with emphysema may have worsening, or exacerbation, of symptoms when they develop a respiratory infection. Symptoms may also be worsened by cigarette smoke, as well as other factors. Following are WHO guidelines for management of exacerbations.
If a person has alpha-1-antitrypsin deficiency, or is a carrier, it is absolutely critical to avoid smoking. Intravenous replacement of the enzyme helps some people, but it is quite expensive.
What are the side effects of the treatments?
Bronchodilators may cause an increased heart rate and blood pressure. Oral glucocorticosteroids can cause increased risk for infection, high blood glucose, and osteoporosis. Antibiotics can cause rash, stomach upset, and allergic reaction.
What happens after treatment for the disease?
Early diagnosis of emphysema and effective treatment can slow its progression. People who eliminate risk factors and follow treatment guidelines have better outcomes. Those who continue to smoke may be increasingly disabled by breathing problems and complications of emphysema.
How is the disease monitored?
Emphysema is monitored through regular visits with the healthcare provider. Lung function tests can be used to monitor limitations in airflow. Any new or worsening symptoms should be reported to the healthcare provider.
Article type: xmedgeneral